Therapeutic Drug Monitoring (TDM)

Drug concentrations that are too high may increase the risk of toxicity, while concentrations that are too low may reduce therapeutic efficacy. Drug Monitoring (TDM) helps clinicians optimize and maintain drug dosing based on a patient’s measured drug levels.

Therapeutic Drug Monitoring (TDM) Assays

Thermo Fisher Scientific

A broad, established TDM menu with excellent accuracy, precision, sensitivity and specificity. Available on a wide range of clinical and specialty chemistry analyzers.

Antibiotics:

  • Amikacin
  • Gentamicin
  • Tobramycin
  • Vancomycin
  • Teicoplanin

Antiepileptics:

  • Carbamazepine
  • Lamotrigine
  • Phenobarbital
  • Phenytoin
  • Topiramate
  • Valproic acid
  • Zonisamide

Cardiovascular & Bronchodilator Drugs:

  • Digoxin
  • Digitoxin
  • Lidocaine
  • Theophylline

Backed by QMS/PAR TDM control sets, plus LabLink xL for real-time, web-based quality assurance.

Therapeutic Drug Monitoring for IBD Biologics

R-Biopharm

Therapeutic drug monitoring (TDM) can help healthcare professionals optimise biologic treatment in patients with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.

R-Biopharm offers a comprehensive range of enzyme immunoassays for monitoring commonly used biologic therapies, including therapeutic drug levels and anti-drug antibodies where applicable.

Enzyme immunoassays:

  • Infliximab (IFX)
  • Adalimumab (ADM)
  • Vedolizumab (VDZ)
  • Golimumab (GLM)
  • Ustekinumab (UST)

The ELISA and rapid test formats use identical monoclonal antibodies and show close correlation between formats.

For infliximab, therapeutic drug levels and anti-drug antibody results can be used with the TAXIT algorithm, a published, evidence-based approach for supporting infliximab dose optimisation.

ARK™ TDM Assays

ARK Diagnostics

Liquid, stable, ready-to-use homogeneous enzyme immunoassays with applications available for clinical chemistry systems extending TDM coverage into newer-generation antiepileptics, antifungals and oncology drug monitoring.

Epilepsy

  • Gabapentin
  • Lacosamide
  • Lamotrigine
  • Levetiracetam
  • Oxcarbazepine Metabolite
  • Topiramate
  • Zonisamide

Other TDM areas:

  • Cancer — Methotrexate
  • Antibiotics — Linezolid
  • Antifungal — Voriconazole II

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